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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ras-related protein Rab-1A

UniprotKB/SwissProt ID: RAB1A_HUMAN (P62820)

Gene Name: RAB1A

Synonyms: RAB1

Organism: Homo sapiens (Human).

Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome (By similarity). Note=Alternates between membrane-associated and cytosolic forms.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map05134Legionellosis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001806
IPR002078
IPR003579
IPR005225
IPR013753

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2FOL X-ray 2.63 A A6-176Link
2WWX X-ray 1.50 A A4-178Link
3L0I X-ray 2.85 A B/D1-177Link
3SFV X-ray 1.73 A A1-176Link
3TKL X-ray 2.18 A A1-191Link
4FMB X-ray 3.20 A B/D/F6-176Link
4FMC X-ray 2.80 A B/D6-176Link
4FMD X-ray 3.05 A B/D6-176Link
F13-176
4FME X-ray 4.10 A B/E6-176Link
4IRU X-ray 3.20 A B/D/F3-177Link
4JVS X-ray 2.78 A B1-177Link

The S-nitrosylation sites of RAB1A_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1126NVNKLLVGNK C DLTTKKVVDY CCEEEEEECC C CCCCCCCCCH 6.34%HC0119483679in vivo