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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ras-related C3 botulinum toxin substrate 1

UniprotKB/SwissProt ID: RAC1_MOUSE (P63001)

Gene Name: Rac1

Organism: Mus musculus (Mouse).

Function: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Melanosome (By similarity). Cytoplasm (By similarity). Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine. Found in the ruffled bo

Network with metabolic pathway:
Kegg map ID Pathway Link
map04664Fc epsilon RI signaling pathway
map05014Amyotrophic lateral sclerosis (ALS)
map04360Axon guidance
map04370VEGF signaling pathway
map04380Osteoclast differentiation
map04520Adherens junction
map04650Natural killer cell mediated cytotoxicity
map04662B cell receptor signaling pathway
map04666Fc gamma R-mediated phagocytosis
map04670Leukocyte transendothelial migration
map04722Neurotrophin signaling pathway
map04972Pancreatic secretion
map05100Bacterial invasion of epithelial cells
map05210Colorectal cancer
map05211Renal cell carcinoma
map05212Pancreatic cancer
map05416Viral myocarditis
map04010MAPK signaling pathway
map04062Chemokine signaling pathway
map04145Phagosome
map04151PI3K-Akt signaling pathway
map04310Wnt signaling pathway
map04510Focal adhesion
map04620Toll-like receptor signaling pathway
map04810Regulation of actin cytoskeleton
map05132Salmonella infection
map05200Pathways in cancer
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001806
IPR003578
IPR005225
IPR013753
The S-nitrosylation sites of RAC1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
16-----MQAIK C VVVGDGAVGK -----CCEEE E EEEECCCCCH 1.99%MC1320925432in vivo
26-----MQAIK C VVVGDGAVGK -----CCEEE E EEEECCCCCH 1.99%MC1322865876in vivo
3105AKWYPEVRHH C PNTPIILVGT HHHHHHHHHH C CCCEEEEEEE 1.96%MC0824895380-
4105AKWYPEVRHH C PNTPIILVGT HHHHHHHHHH C CCCEEEEEEE 1.96%MC0820925432in vivo
5105AKWYPEVRHH C PNTPIILVGT HHHHHHHHHH C CCCEEEEEEE 1.96%MC0821278135in vitro
6105AKWYPEVRHH C PNTPIILVGT HHHHHHHHHH C CCCEEEEEEE 1.96%MC0822865876in vivo
7157KEIGAVKYLE C SALTQRGLKT HHHCCEEEEE E EECCCCCHHH 2.38%MC0224895380-
8157KEIGAVKYLE C SALTQRGLKT HHHCCEEEEE E EECCCCCHHH 2.38%MC0220925432in vivo
9157KEIGAVKYLE C SALTQRGLKT HHHCCEEEEE E EECCCCCHHH 2.38%MC0221278135in vitro
10178VFDEAIRAVL C PPPVKKRKRK HHHHHHHHHH C CCCCCCCCCC 3.70%MC0224895380-
11178VFDEAIRAVL C PPPVKKRKRK HHHHHHHHHH C CCCCCCCCCC 3.70%MC0221278135in vitro