Protein Name: GTP-binding nuclear protein Ran
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UniprotKB/SwissProt ID: RAN_MOUSE (P62827)
Gene Name: Ran
Synonyms: Rasl2-8
Organism: Mus musculus (Mouse).
Function: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Melanosome (By similarity). Note=Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis.
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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