dbSNO 2.0

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Protein Name: GTPase HRas

UniprotKB/SwissProt ID: RASH_HUMAN (P01112)

Gene Name: HRAS

Synonyms: HRAS1

Organism: Homo sapiens (Human).

Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles betwe

PDB :
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Protein disease:

Disease database	Database Entry	Disease information
KEGG	H00022	Bladder cancer
KEGG	H00025	Penile cancer
KEGG	H00030	Cervical cancer
KEGG	H00032	Thyroid cancer
KEGG	H00040	Squamous cell carcinoma
KEGG	H00048	Hepatocellular carcinoma
KEGG	H00523	Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noona
OMIM	109800	BLADDER CANCER
OMIM	162900	NEVUS, EPIDERMAL ;;PIGMENTED MOLES;; NEVUS, KERATINOCYTIC, NONEPIDERMOLYTIC
OMIM	163200	SCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROME ;;SFM SYNDROME;; LINEAR SEBACEOUS NEVUS SYNDROME;;
OMIM	188470	THYROID CARCINOMA, FOLLICULAR; FTC
OMIM	190020	V-HA-RAS HARVEY RAT SARCOMA VIRAL ONCOGENE HOMOLOG; HRAS ;;HRAS1;; HARVEY MURINE SARCOMA VIR
OMIM	218040	COSTELLO SYNDROME ;;FACIOCUTANEOSKELETAL SYNDROME;; FCS SYNDROME MYOPATHY, CONGENITAL, WITH
HPRD	01813	Bladder cancer, somatic
HPRD	01813	Costello syndrome
HPRD	01813	Thyroid carcinoma, follicular, somatic

Network with metabolic pathway:

Kegg map ID	Pathway	Link
map04664	Fc epsilon RI signaling pathway
map04720	Long-term potentiation
map05213	Endometrial cancer
map05216	Thyroid cancer
map05219	Bladder cancer
map05221	Acute myeloid leukemia
map05223	Non-small cell lung cancer
map04360	Axon guidance
map04370	VEGF signaling pathway
map04540	Gap junction
map04650	Natural killer cell mediated cytotoxicity
map04660	T cell receptor signaling pathway
map04662	B cell receptor signaling pathway
map04722	Neurotrophin signaling pathway
map04725	Cholinergic synapse
map04726	Serotonergic synapse
map04730	Long-term depression
map04912	GnRH signaling pathway
map05160	Hepatitis C
map05211	Renal cell carcinoma
map05214	Glioma
map05215	Prostate cancer
map05218	Melanoma
map05220	Chronic myeloid leukemia
map04010	MAPK signaling pathway
map04012	ErbB signaling pathway
map04062	Chemokine signaling pathway
map04151	PI3K-Akt signaling pathway
map04510	Focal adhesion
map04530	Tight junction
map04810	Regulation of actin cytoskeleton
map04910	Insulin signaling pathway
map04916	Melanogenesis
map05034	Alcoholism
map05161	Hepatitis B
map05166	HTLV-I infection
map05200	Pathways in cancer
map05203	Viral carcinogenesis
map04144	Endocytosis
map04320	Dorso-ventral axis formation
map04960	Aldosterone-regulated sodium reabsorption
map05210	Colorectal cancer
map05212	Pancreatic cancer
map04914	Progesterone-mediated oocyte maturation

Graphical Visualization of S-nitrosylation Sites:

Overview of Protein S-nitrosylation Sites with Functional and Structural Information

InterPro ID	Domain
IPR001806
IPR003577
IPR005225
IPR013753
IPR015592

3D Structure Databases:


3D structure databases
Entry	Method	Resolution (A)	Chain	Positions	View
121P	X-ray	1.54 A	A	1-166	Link
1AA9	NMR	-	A	1-171	Link
1AGP	X-ray	2.30 A	A	1-166	Link
1BKD	X-ray	2.80 A	R	1-166	Link
1CLU	X-ray	1.70 A	A	1-166	Link
1CRP	NMR	-	A	1-166	Link
1CRQ	NMR	-	A	1-166	Link
1CRR	NMR	-	A	1-166	Link
1CTQ	X-ray	1.26 A	A	1-166	Link
1GNP	X-ray	2.70 A	A	1-166	Link
1GNQ	X-ray	2.50 A	A	1-166	Link
1GNR	X-ray	1.85 A	A	1-166	Link
1HE8	X-ray	3.00 A	B	1-166	Link
1IAQ	X-ray	2.90 A	A/B/C	1-166	Link
1IOZ	X-ray	2.00 A	A	1-171	Link
1JAH	X-ray	1.80 A	A	1-166	Link
1JAI	X-ray	1.80 A	A	1-166	Link
1K8R	X-ray	3.00 A	A	1-166	Link
1LF0	X-ray	1.70 A	A	1-166	Link
1LF5	X-ray	1.70 A	A	1-166	Link
1LFD	X-ray	2.10 A	B/D	1-167	Link
1NVU	X-ray	2.20 A	Q/R	1-166	Link
1NVV	X-ray	2.18 A	Q/R	1-166	Link
1NVW	X-ray	2.70 A	Q/R	1-166	Link
1NVX	X-ray	3.20 A	Q/R	1-166	Link
1P2S	X-ray	2.45 A	A	1-166	Link
1P2T	X-ray	2.00 A	A	1-166	Link
1P2U	X-ray	2.00 A	A	1-166	Link
1P2V	X-ray	2.30 A	A	1-166	Link
1PLJ	X-ray	2.80 A	A	1-166	Link
1PLK	X-ray	2.80 A	A	1-166	Link
1PLL	X-ray	2.80 A	A	1-166	Link
1Q21	X-ray	2.20 A	A	1-171	Link
1QRA	X-ray	1.60 A	A	1-166	Link
1RVD	X-ray	1.90 A	A	1-166	Link
1WQ1	X-ray	2.50 A	R	1-166	Link
1XCM	X-ray	1.84 A	A	1-167	Link
1XD2	X-ray	2.70 A	A/B	1-166	Link
1XJ0	X-ray	1.70 A	A	1-166	Link
1ZVQ	X-ray	2.00 A	A	1-166	Link
1ZW6	X-ray	1.50 A	A	1-166	Link
221P	X-ray	2.30 A	A	1-166	Link
2C5L	X-ray	1.90 A	A/B	1-166	Link
2CE2	X-ray	1.00 A	X	1-166	Link
2CL0	X-ray	1.80 A	X	1-166	Link
2CL6	X-ray	1.24 A	X	1-166	Link
2CL7	X-ray	1.25 A	X	1-166	Link
2CLC	X-ray	1.30 A	X	1-166	Link
2CLD	X-ray	1.22 A	X	1-166	Link
2EVW	X-ray	1.05 A	X	1-166	Link
2GDP	Model	-	A	1-171	Link
2LCF	NMR	-	A	1-166	Link
2LWI	NMR	-	A	1-166	Link
2Q21	X-ray	2.20 A	A	1-171	Link
2QUZ	X-ray	1.49 A	A	1-166	Link
2RGA	X-ray	1.90 A	A	1-166	Link
2RGB	X-ray	1.35 A	A	1-166	Link
2RGC	X-ray	1.60 A	A	1-166	Link
2RGD	X-ray	2.00 A	A	1-166	Link
2RGE	X-ray	1.40 A	A	1-166	Link
2RGG	X-ray	1.45 A	A	1-166	Link
2UZI	X-ray	2.00 A	R	1-166	Link
2VH5	X-ray	2.70 A	R	1-166	Link
2X1V	X-ray	1.70 A	A	1-166	Link
3DDC	X-ray	1.80 A	A	1-166	Link
3I3S	X-ray	1.36 A	R	1-166	Link
3K8Y	X-ray	1.30 A	A	1-166	Link
3K9L	X-ray	1.80 A	A/B/C	1-166	Link
3K9N	X-ray	2.00 A	A	1-166	Link
3KKM	X-ray	1.70 A	A	1-166	Link
3KKN	X-ray	2.09 A	A	1-166	Link
3KUD	X-ray	2.15 A	A	1-166	Link
3L8Y	X-ray	2.02 A	A	1-166	Link
3L8Z	X-ray	1.44 A	A	1-166	Link
3LBH	X-ray	1.85 A	A	1-166	Link
3LBI	X-ray	2.09 A	A	1-166	Link
3LBN	X-ray	1.86 A	A	1-166	Link
3LO5	X-ray	2.57 A	A/C/E	1-166	Link
3OIU	X-ray	1.32 A	A	1-166	Link
3OIV	X-ray	1.84 A	A	1-166	Link
3OIW	X-ray	1.30 A	A	1-166	Link
3RRY	X-ray	1.60 A	A	1-166	Link
3RRZ	X-ray	1.60 A	A	1-166	Link
3RS0	X-ray	1.40 A	A	1-166	Link
3RS2	X-ray	1.84 A	A	1-166	Link
3RS3	X-ray	1.52 A	A	1-166	Link
3RS4	X-ray	1.70 A	A	1-166	Link
3RS5	X-ray	1.68 A	A	1-166	Link
3RS7	X-ray	1.70 A	A	1-166	Link
3RSL	X-ray	1.70 A	A	1-166	Link
3RSO	X-ray	1.60 A	A	1-166	Link
3TGP	X-ray	1.31 A	A	1-166	Link
421P	X-ray	2.20 A	A	1-166	Link
4DLR	X-ray	1.32 A	A	1-166	Link
4DLS	X-ray	1.82 A	A	1-166	Link
4DLT	X-ray	1.70 A	A	1-166	Link
4DLU	X-ray	1.60 A	A	1-166	Link
4DLV	X-ray	1.57 A	A	1-166	Link
4DLW	X-ray	1.72 A	A	1-166	Link
4DLX	X-ray	1.73 A	A	1-166	Link
4DLY	X-ray	1.57 A	A	1-166	Link
4DLZ	X-ray	1.66 A	A	1-166	Link
4DST	X-ray	2.30 A	A	2-167	Link
4DSU	X-ray	1.70 A	A	2-167	Link
4EFL	X-ray	1.90 A	A	1-166	Link
4EFM	X-ray	1.90 A	A	1-166	Link
4EFN	X-ray	2.30 A	A	1-166	Link
4G0N	X-ray	2.45 A	A	1-166	Link
4G3X	X-ray	3.25 A	A	1-166	Link
4K81	X-ray	2.40 A	B/D/F/H	1-166	Link
4L9S	X-ray	1.61 A	A	1-166	Link
4L9W	X-ray	1.95 A	A	1-166	Link
4Q21	X-ray	2.00 A	A	1-189	Link
521P	X-ray	2.60 A	A	1-166	Link
5P21	X-ray	1.35 A	A	1-166	Link
621P	X-ray	2.40 A	A	1-166	Link
6Q21	X-ray	1.95 A	A/B/C/D	1-171	Link
721P	X-ray	2.00 A	A	1-166	Link
821P	X-ray	1.50 A	A	1-166	Link

The S-nitrosylation sites of RASH_HUMAN

No.	Position	S-nitrosylated Peptide	Secondary Structure of S-nitrosylated Peptide	Solvent Accessibility of nitrosylated Site	Substrate Motifs	PubMed ID	Experiment
1	80	QYMRTGEGFL C VFAINNTKSF	HHHCCCCEEE E EEECCCHHHH	1.90%	HC01	24105792	-
2	118	DVPMVLVGNK C DLAARTVESR	CCEEEEEEEC C CCCCCCCCHH	6.34%	HC02	24105792	-
3	118	DVPMVLVGNK C DLAARTVESR	CCEEEEEEEC C CCCCCCCCHH	6.34%	HC02	9020151	in vitro
4	181	LNPPDESGPG C MSCKCVLS--	CCCCCCCCCC C CCCCCEEC	1.72%	HC12	24105792	-

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