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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: E3 ubiquitin-protein ligase RBX1

UniprotKB/SwissProt ID: RBX1_MOUSE (P62878)

Gene Name: Rbx1

Organism: Mus musculus (Mouse).

Function: E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M (By similarity). Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity). In concert with ATF2 and CUL3, promotes degradation of KAT5 attenuating its ability to acetylate and activate ATM (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Nucleus (By similarity).

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04710Circadian rhythm
map04066HIF-1 signaling pathway
map05211Renal cell carcinoma
map04110Cell cycle
map04114Oocyte meiosis
map04310Wnt signaling pathway
map04350TGF-beta signaling pathway
map05200Pathways in cancer
map03420Nucleotide excision repair
map04120Ubiquitin mediated proteolysis
map04141Protein processing in endoplasmic reticulum
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001841
IPR013083

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
4A0C X-ray 3.80 A D/F12-108Link
4A0K X-ray 5.93 A B12-108Link
4A0L X-ray 7.40 A F/I12-108Link

The S-nitrosylation sites of RBX1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
194ISRWLKTRQV C PLDNREWEFQ HHHHHHHCCC C CCCCCEEEEE 1.78%MC0421278135in vitro