UniprotKB/SwissProt ID: RECQ5_HUMAN (O94762)
Gene Name: RECQL5
Synonyms: RECQ5
Organism: Homo sapiens (Human).
Function: Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Isoform Beta: Nucleus, nucleoplasm. Note=Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks. Isoform Alpha: Cytoplasm. Isoform Gamma: Cytoplasm.
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