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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Rho-related GTP-binding protein RhoC

UniprotKB/SwissProt ID: RHOC_MOUSE (Q62159)

Gene Name: Rhoc

Synonyms: Arhc

Organism: Mus musculus (Mouse).

Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cleavage furrow (By similarity). Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner (By similarity).

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001806
IPR003578
IPR005225
IPR013753

The S-nitrosylation sites of RHOC_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
116KKLVIVGDGA C GKTCLLIVFS EEEEEEECCC C CHHHHHHHHH 7.60%MC0621278135in vitro
2107EKWTPEVKHF C PNVPIILVGN HHHHHHHHHH C CCCEEEEEEE 2.10%MC0820925432in vivo
3107EKWTPEVKHF C PNVPIILVGN HHHHHHHHHH C CCCEEEEEEE 2.10%MC0821278135in vitro
4159NRISAFGYLE C SAKTKEGVRE HHCCCCEEEE E EECCCCCHHH 4.41%MC0321278135in vitro