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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: DNA-directed RNA polymerases I and III subunit RPAC1

UniprotKB/SwissProt ID: RPAC1_HUMAN (O15160)

Gene Name: POLR1C

Synonyms: POLR1E

Organism: Homo sapiens (Human).

Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00230Purine metabolism
map00240Pyrimidine metabolism
map04623Cytosolic DNA-sensing pathway
map05169Epstein-Barr virus infection
map03020RNA polymerase
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information