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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ras-related protein R-Ras2

UniprotKB/SwissProt ID: RRAS2_HUMAN (P62070)

Gene Name: RRAS2

Synonyms: TC21

Organism: Homo sapiens (Human).

Function: It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
OMIM600098RELATED RAS VIRAL ONCOGENE HOMOLOG 2; RRAS2 ;;ONCOGENE RRAS2;; TERATOCARCINOMA ONCOGENE TC21
HPRD02518Ovarian carcinoma
Network with metabolic pathway:
Kegg map ID Pathway Link
map04010MAPK signaling pathway
map04530Tight junction
map04810Regulation of actin cytoskeleton
map05166HTLV-I infection
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001806
IPR003577
IPR005225
IPR013753

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2ERY X-ray 1.70 A A/B12-181Link

The S-nitrosylation sites of RRAS2_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
155PTIEDSYTKQ C VIDDRAARLD CCEEEEEEEE E EECCEEEEEE 2.86%HC0321278135in vitro
2183RVIRKFQEQE C PPSPEPTRKE HHHHHHHHCC C CCCCCCCCCC 6.33%HC0121278135in vitro