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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: 30S ribosomal protein S4

UniprotKB/SwissProt ID: RS4_ECOLI (P0A7V8)

Gene Name: rpsD

Synonyms: ramA

Organism: Escherichia coli (strain K12).

Function: One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. With S5 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations). Plays a role in mRNA unwinding by the ribosome, possibly by forming part of a processivity clamp. Protein S4 is also a translational repressor protein, it controls the translation of the alpha-operon (which codes for S13, S11, S4, RNA polymerase alpha subunit, and L17) by binding to its mRNA. Also functions as a rho-dependent antiterminator of rRNA transcription, increasing the synthesis of rRNA under conditions of excess protein, allowing a more rapid return to homeostasis. Binds directly to RNA polymerase.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
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Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001912
IPR002942
IPR005709
3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1EG0 EM 11.50 A A43-200Link
1M5G Model - D2-206Link
1P6G EM 12.30 A D2-206Link
1P87 EM 11.50 A D2-206Link
1VS5 X-ray 3.46 A D1-206Link
1VS7 X-ray 3.46 A D1-206Link
2AVY X-ray 3.46 A D2-206Link
2AW7 X-ray 3.46 A D2-206Link
2GY9 EM 15.00 A D3-205Link
2GYB EM 15.00 A D3-205Link
2I2P X-ray 3.22 A D2-205Link
2I2U X-ray 3.22 A D2-205Link
2QAL X-ray 3.21 A D2-206Link
2QAN X-ray 3.21 A D2-206Link
2QB9 X-ray 3.54 A D2-206Link
2QBB X-ray 3.54 A D2-206Link
2QBD X-ray 3.30 A D2-206Link
2QBF X-ray 3.30 A D2-206Link
2QBH X-ray 4.00 A D2-206Link
2QBJ X-ray 4.00 A D2-206Link
2QOU X-ray 3.93 A D2-206Link
2QOW X-ray 3.93 A D2-206Link
2QOY X-ray 3.50 A D2-206Link
2QP0 X-ray 3.50 A D2-206Link
2VHP X-ray 3.74 A D2-206Link
2WWL EM 5.80 A D2-206Link
2YKR EM 9.80 A D2-206Link
2Z4K X-ray 4.45 A D2-206Link
2Z4M X-ray 4.45 A D2-206Link
3DF1 X-ray 3.50 A D2-205Link
3DF3 X-ray 3.50 A D2-205Link
3E1A EM - R1-206Link
3E1C EM - R1-206Link
3FIH EM 6.70 A D2-206Link
3I1M X-ray 3.19 A D1-206Link
3I1O X-ray 3.19 A D1-206Link
3I1Q X-ray 3.81 A D1-206Link
3I1S X-ray 3.81 A D1-206Link
3I1Z X-ray 3.71 A D1-206Link
3I21 X-ray 3.71 A D1-206Link
3IZV EM - H1-206Link
3IZW EM - H1-206Link
3J00 EM - D2-206Link
3J0U EM 12.10 A G2-206Link
3J0V EM 14.70 A G2-206Link
3J0X EM 13.50 A G2-206Link
3J0Z EM 11.50 A G2-206Link
3J10 EM 11.50 A G2-206Link
3J13 EM 13.10 A F2-206Link
3J18 EM 8.30 A D2-206Link
3J36 EM 9.80 A D2-206Link
3J4V EM 12.00 A D1-206Link
3J4W EM 12.00 A D1-206Link
3J4Y EM 17.00 A D1-206Link
3J4Z EM 20.00 A D1-206Link
3J53 EM 13.00 A D1-206Link
3J55 EM 15.00 A D1-206Link
3J57 EM 17.00 A D1-206Link
3J59 EM 12.00 A D1-206Link
3J5B EM 17.00 A D1-206Link
3J5D EM 17.00 A D1-206Link
3J5F EM 20.00 A D1-206Link
3J5H EM 15.00 A D1-206Link
3J5J EM 9.00 A D1-206Link
3J5N EM 6.80 A D1-206Link
3J5T EM 7.60 A D2-206Link
3J5X EM 7.60 A D2-206Link
3KC4 EM - D1-206Link
3OAQ X-ray 3.25 A D2-206Link
3OAR X-ray 3.25 A D2-206Link
3OFA X-ray 3.19 A D2-206Link
3OFB X-ray 3.19 A D2-206Link
3OFO X-ray 3.10 A D2-206Link
3OFP X-ray 3.10 A D2-206Link
3OFX X-ray 3.29 A D2-206Link
3OFY X-ray 3.29 A D2-206Link
3OR9 X-ray 3.30 A D1-206Link
3ORA X-ray 3.30 A D1-206Link
3SFS X-ray 3.20 A D1-206Link
3UOQ X-ray 3.70 A D1-206Link
4A2I EM 16.50 A D2-206Link
4ADV EM 13.50 A D2-206Link
4GAQ X-ray 3.30 A D1-206Link
4GAS X-ray 3.30 A D1-206Link
4GD1 X-ray 3.00 A D2-206Link
4GD2 X-ray 3.00 A D2-206Link
4KIY X-ray 2.90 A D1-206Link
4KJ0 X-ray 2.90 A D1-206Link
4KJ2 X-ray 2.90 A D1-206Link
4KJ4 X-ray 2.90 A D1-206Link
4KJ6 X-ray 2.90 A D1-206Link
4KJ8 X-ray 2.90 A D1-206Link
4KJA X-ray 2.90 A D1-206Link
4KJC X-ray 2.90 A D1-206Link
The S-nitrosylation sites of RS4_ECOLI

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
132KSGVRAIDTK C KIEQAPGQHG CCCCCCCCCC C CCCCCCCCCC 6.11%EC0122178444-
232KSGVRAIDTK C KIEQAPGQHG CCCCCCCCCC C CCCCCCCCCC 6.11%EC0119483679in vitro