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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Protein S100-A1

UniprotKB/SwissProt ID: S10A1_HUMAN (P23297)

Gene Name: S100A1

Synonyms: S100A

Organism: Homo sapiens (Human).

Function: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001751
IPR002048
IPR011992
IPR013787

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2L0P NMR - A/B1-94Link
2LHL NMR - A/B2-94Link
2LLS NMR - A/B2-94Link
2LLT NMR - A/B2-94Link
2LLU NMR - A/B2-94Link
2LP2 NMR - A/B2-94Link
2LP3 NMR - A/B2-94Link
2LUX NMR - A/B2-94Link

The S-nitrosylation sites of S10A1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
186VVLVAALTVA C NNFFWENS-- HHHHHHHHHH H HHHHHHCC 3.58%HC1222178444-
286VVLVAALTVA C NNFFWENS-- HHHHHHHHHH H HHHHHHCC 3.58%HC1215590070-