UniprotKB/SwissProt ID: S27A2_MOUSE (O35488)
Gene Name: Slc27a2
Synonyms: Acsvl1, Facvl1, Fatp2, Vlacs, Vlcs
Organism: Mus musculus (Mouse).
Function: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism (By similarity). May be involved in translocation of long-chain fatty acids (LFCA) across membranes.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Peroxisome membrane; Multi-pass membrane protein (By similarity). Note=Peripheral membrane associated with the lumenal side of peroxisomes (By similarity).
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