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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Protein transport protein Sec61 subunit alpha isoform 1

UniprotKB/SwissProt ID: S61A1_MOUSE (P61620)

Gene Name: Sec61a1

Synonyms: Sec61a

Organism: Mus musculus (Mouse).

Function: Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adaptor proteins.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04145Phagosome
map04141Protein processing in endoplasmic reticulum
map03060Protein export
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002208

The S-nitrosylation sites of S61A1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
113IKFLEVIKPF C VILPEIQKPE CHHHHHHHHH H HHCHHHHCCC 2.23%MC0822178444-
213IKFLEVIKPF C VILPEIQKPE CHHHHHHHHH H HHCHHHHCCC 2.23%MC0820925432in vivo
313IKFLEVIKPF C VILPEIQKPE CHHHHHHHHH H HHCHHHHCCC 2.23%MC0820837516in vivo