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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Adenosylhomocysteinase

UniprotKB/SwissProt ID: SAHH_HUMAN (P23526)

Gene Name: AHCY

Synonyms: SAHH

Organism: Homo sapiens (Human).

Function: Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD01621Hypermethioninemia with deficiency of s-adenosylhomocysteine hydrolase
Network with metabolic pathway:
Kegg map ID Pathway Link
map00270Cysteine and methionine metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000043
IPR015878

The S-nitrosylation sites of SAHH_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1195TKSKFDNLYG C RESLIDGIKR HHHHHCCCCC C HHHHHHHHHH 2.49%HC1124105792-