Protein Name: Protein scribble homolog
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UniprotKB/SwissProt ID: SCRIB_HUMAN (Q14160)
Gene Name: SCRIB
Synonyms: CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Organism: Homo sapiens (Human).
Function: Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Note=Targeting to cell-cell junctions which is CDH1- dependent is required for the pro-apoptotic activity. Localizes to neuronal post
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 607733 | SCRIBBLE, DROSOPHILA, HOMOLOG OF; SCRIB ;;SCRIBBLE 1; SCRB1;; CIRCLETAIL, MOUSE, HOMOLOG OF; |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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