UniprotKB/SwissProt ID: SF3B1_HUMAN (O75533)
Gene Name: SF3B1
Synonyms: SAP155
Organism: Homo sapiens (Human).
Function: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.
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