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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Pulmonary surfactant-associated protein D

UniprotKB/SwissProt ID: SFTPD_HUMAN (P35247)

Gene Name: SFTPD

Synonyms: COLEC7, PSPD, SFTP4

Organism: Homo sapiens (Human).

Function: Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04145Phagosome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001304
IPR008160
IPR008161
IPR015097

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1B08 X-ray 2.30 A A/B/C224-375Link
1M7L NMR - A/B/C220-257Link
1PW9 X-ray 1.60 A A/B/C201-375Link
1PWB X-ray 1.40 A A/B/C201-375Link
2GGU X-ray 1.90 A A/B/C223-375Link
2GGX X-ray 1.90 A A/B/C223-375Link
2ORJ X-ray 1.80 A A/B/C223-375Link
2ORK X-ray 1.89 A A/B/C223-375Link
2OS9 X-ray 1.70 A A/B/C223-375Link
2RIA X-ray 1.80 A A/B/C223-375Link
2RIB X-ray 1.80 A A/B/C223-375Link
2RIC X-ray 1.80 A A/B/C223-375Link
2RID X-ray 1.80 A A/B/C223-375Link
2RIE X-ray 1.60 A A/B/C223-375Link
3DBZ X-ray 1.80 A A/B/C223-375Link
3G81 X-ray 1.80 A A/B/C223-375Link
3G83 X-ray 1.90 A A/B/C223-375Link
3G84 X-ray 2.30 A A/B/C223-375Link
3IKN X-ray 1.60 A A/B/C201-375Link
3IKP X-ray 1.75 A A/B/C201-375Link
3IKQ X-ray 2.25 A A/B/C201-375Link
3IKR X-ray 1.65 A A/B/C201-375Link
4E52 X-ray 1.70 A A/B/C201-375Link
4M17 X-ray 2.10 A A/B/C/D/E/F/G/H/I/J/K/L229-375Link
4M18 X-ray 3.20 A A/B/C/D/E/F/G/H/I/J/K/L229-375Link

The S-nitrosylation sites of SFTPD_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
135TYSHRTMPSA C TLVMCSSVES CCCCCCCCCC C CCCCCCCCCC 3.38%HC0122178444-
235TYSHRTMPSA C TLVMCSSVES CCCCCCCCCC C CCCCCCCCCC 3.38%HC0119007302-
340TMPSACTLVM C SSVESGLPGR CCCCCCCCCC C CCCCCCCCCC 1.82%HC1222178444-
440TMPSACTLVM C SSVESGLPGR CCCCCCCCCC C CCCCCCCCCC 1.82%HC1219007302-