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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Small nuclear ribonucleoprotein Sm D2

UniprotKB/SwissProt ID: SMD2_HUMAN (P62316)

Gene Name: SNRPD2

Synonyms: SNRPD1

Organism: Homo sapiens (Human).

Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Nucleus. Note=SMN- mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.

PDB :
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Network with metabolic pathway:
Kegg map ID Pathway Link
map03040Spliceosome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001163
IPR006649
IPR010920

The S-nitrosylation sites of SMD2_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
163LGRVKAFDRH C NMVLENVKEM EEEEEEEEHH H HHHHHHHHHH 3.51%HC022212679
(Cys53)
in vitro
263LGRVKAFDRH C NMVLENVKEM EEEEEEEEHH H HHHHHHHHHH 3.51%HC0225040305in vivo