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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Superoxide dismutase [Cu-Zn]

UniprotKB/SwissProt ID: SODC_HUMAN (P00441)

Gene Name: SOD1

Organism: Homo sapiens (Human).

Function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.

PDB :
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Protein disease:
Disease database Database Entry Disease information
HPRD00937Amyotrophic lateral sclerosis 1
HPRD00937Amyotrophic lateral sclerosis 1, autosomal recessive
HPRD00937Amyotrophic lateral sclerosis, sporadic
Network with metabolic pathway:
Kegg map ID Pathway Link
map05014Amyotrophic lateral sclerosis (ALS)
map05020Prion diseases
map04146Peroxisome
map05016Huntington's disease
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001424
3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1AZV X-ray 1.90 A A/B2-154Link
1BA9 NMR - A2-154Link
1DSW NMR - A2-154Link
1FUN X-ray 2.85 A A/B/C/D/E/F/G/H/I/J2-153Link
1HL4 X-ray 1.82 A A/B/C/D2-154Link
1HL5 X-ray 1.80 A A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/S2-154Link
1KMG NMR - A2-153Link
1L3N NMR - A/B2-153Link
1MFM X-ray 1.02 A A2-154Link
1N18 X-ray 2.00 A A/B/C/D/E/F/G/H/I/J1-154Link
1N19 X-ray 1.86 A A/B1-154Link
1OEZ X-ray 2.15 A W/X/Y/Z2-154Link
1OZT X-ray 2.50 A G/H/I/J/K/L/M/N2-154Link
1OZU X-ray 1.30 A A/B2-154Link
1P1V X-ray 1.40 A A/B/C2-153Link
1PTZ X-ray 1.80 A A/B2-154Link
1PU0 X-ray 1.70 A A/B/C/D/E/F/G/H/I/J2-154Link
1RK7 NMR - A2-154Link
1SOS X-ray 2.50 A A/B/C/D/E/F/G/H/I/J2-154Link
1SPD X-ray 2.40 A A/B2-154Link
1UXL X-ray 1.60 A A/B/C/D/E/F/G/H/I/J2-154Link
1UXM X-ray 1.90 A A/B/C/D/E/F/G/H/I/J/K/L2-154Link
2AF2 NMR - A/B2-154Link
2C9S X-ray 1.24 A A/F2-154Link
2C9U X-ray 1.24 A A/F2-154Link
2C9V X-ray 1.07 A A/F2-154Link
2GBT X-ray 1.70 A A/B/C/D2-154Link
2GBU X-ray 2.00 A A/B/C/D2-154Link
2GBV X-ray 2.00 A A/B/C/D/E/F/G/H/I/J2-154Link
2LU5 NMR - A2-154Link
2NNX X-ray 2.30 A A/B/C/D2-153Link
2R27 X-ray 2.00 A A/B1-154Link
2V0A X-ray 1.15 A A/F2-154Link
2VR6 X-ray 1.30 A A/F2-154Link
2VR7 X-ray 1.58 A A/F2-154Link
2VR8 X-ray 1.36 A A/F2-154Link
2WKO X-ray 1.97 A A/F2-154Link
2WYT X-ray 1.00 A A/F2-154Link
2WYZ X-ray 1.70 A A/F2-154Link
2WZ0 X-ray 1.72 A A/F2-154Link
2WZ5 X-ray 1.50 A A/F2-154Link
2WZ6 X-ray 1.55 A A/F2-154Link
2XJK X-ray 1.45 A A2-154Link
2XJL X-ray 1.55 A A2-154Link
2ZKW X-ray 1.90 A A/B1-154Link
2ZKX X-ray 2.72 A A/B/C/D1-154Link
2ZKY X-ray 2.40 A A/B/C/D/E/F/G/H/I/J1-154Link
3CQP X-ray 1.95 A A/B/C/D2-154Link
3CQQ X-ray 1.90 A A/B2-154Link
3ECU X-ray 1.90 A A/B/C/D2-154Link
3ECV X-ray 1.90 A A/B/C/D2-154Link
3ECW X-ray 2.15 A A/B/C/D2-154Link
3GQF X-ray 2.20 A A/B/C/D/E/F2-154Link
3GTV X-ray 2.20 A A/B/C/D/E/F/G/H/I/J/K/L2-81Link
3GZO X-ray 2.10 A A/B/C/D/E/F/G/H/I/J2-154Link
3GZP X-ray 3.10 A A/B/C/D2-154Link
3GZQ X-ray 1.40 A A/B2-154Link
3H2P X-ray 1.55 A A/B2-154Link
3H2Q X-ray 1.85 A A/B/C/D2-154Link
3HFF X-ray 2.20 A A2-154Link
3K91 X-ray 1.75 A A/B2-154Link
3KH3 X-ray 3.50 A A/B/C/D/E/F/G/H/I/J/K/L2-154Link
3KH4 X-ray 3.50 A A/B/C/D/E/F2-154Link
3LTV X-ray 2.45 A A/B/C/D/E/F4-154Link
3QQD X-ray 1.65 A A/B2-154Link
3RE0 X-ray 2.28 A A/B/C/D2-154Link
3T5W X-ray 1.80 A A/B/D/E/F/G/H/I/J/K/L/M2-154Link
4A7G X-ray 1.24 A A/F2-154Link
4A7Q X-ray 1.22 A A/F2-154Link
4A7S X-ray 1.06 A A/F2-154Link
4A7T X-ray 1.45 A A/F2-154Link
4A7U X-ray 0.98 A A/F2-154Link
4A7V X-ray 1.00 A A/F2-154Link
4B3E X-ray 2.15 A A/B/C/D/E/F/G/H/I/J1-154Link
4BCY X-ray 1.27 A A2-154Link
4BCZ X-ray 1.93 A A/B2-154Link
4BD4 X-ray 2.78 A A/B/C/D/E/F/G/H/I2-154Link
4FF9 X-ray 2.50 A A/B2-154Link
4NIN X-ray 1.40 A A102-108Link
4NIO X-ray 1.30 A A148-154Link
4NIP X-ray 1.90 A A148-154Link
4SOD Model - A1-154Link
The S-nitrosylation sites of SODC_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
17----MATKAV C VLKGDGPVQG ----CCEEEE E EECCCCCEEE 3.38%HC0424105792-
27----MATKAV C VLKGDGPVQG ----CCEEEE E EECCCCCEEE 3.38%HC0425040305in vivo
37----MATKAV C VLKGDGPVQG ----CCEEEE E EECCCCCEEE 3.38%HC0419483679in vivo