UniprotKB/SwissProt ID: SPAST_HUMAN (Q9UBP0)
Gene Name: SPAST
Synonyms: ADPSP, FSP2, KIAA1083, SPG4
Organism: Homo sapiens (Human).
Function: ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. May also play a role in axon growth and the formation of axonal branches.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane; Single-pass membrane protein (Potential). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Endoplasmic reticulum. Endosome. Nucleus. Cytoplasm, cytoskeleton, spindle. No
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