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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cornifin-A

UniprotKB/SwissProt ID: SPR1A_HUMAN (P35321)

Gene Name: SPRR1A

Organism: Homo sapiens (Human).

Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR003267
IPR003302
IPR004829

The S-nitrosylation sites of SPR1A_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
141EPCIPKTKEP C HPKVPEPCHP CCCCCCCCCC C CCCCCCCCCC 10.08%HC0424105792-
249EPCHPKVPEP C HPKVPEPCQP CCCCCCCCCC C CCCCCCCCCC 9.05%HC1124105792-
357EPCHPKVPEP C QPKVPEPCQP CCCCCCCCCC C CCCCCCCCCC 11.74%HC1124105792-