dbSNO 2.0

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Protein Name: Sepiapterin reductase

UniprotKB/SwissProt ID: SPRE_MOUSE (Q64105)

Gene Name: Spr

Organism: Mus musculus (Mouse).

Function: Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
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Graphical Visualization of S-nitrosylation Sites:

Overview of Protein S-nitrosylation Sites with Functional and Structural Information

InterPro ID	Domain
IPR002198
IPR002347
IPR006393

3D Structure Databases:


3D structure databases
Entry	Method	Resolution (A)	Chain	Positions	View
1NAS	X-ray	2.10 A	A	3-261	Link
1OAA	X-ray	1.25 A	A	3-261	Link
1SEP	X-ray	1.95 A	A	1-261	Link

The S-nitrosylation sites of SPRE_MOUSE

No.	Position	S-nitrosylated Peptide	Secondary Structure of S-nitrosylated Peptide	Solvent Accessibility of nitrosylated Site	Substrate Motifs	PubMed ID	Experiment
1	160	SKTVVNISSL C ALQPYKGWGL	CCEEEEECHH H HCCCCCCCHH	3.72%	MC02	21278135	in vitro
2	172	LQPYKGWGLY C AGKAARDMLY	CCCCCCCHHH H HHHHHHHHHH	4.91%	MC02	21278135	in vitro
3	235	KLKSDGALVD C GTSAQKLLGL	HCCCCCCCCC H HHHHHHHHHH	5.09%	MC02	21278135	in vitro

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