UniprotKB/SwissProt ID: SQSTM_MOUSE (Q64337)
Gene Name: Sqstm1
Synonyms: A170, STAP
Organism: Mus musculus (Mouse).
Function: Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Late endosome. Nucleus. Endoplasmic reticulum. Lysosome (By similarity). Cytoplasmic vesicle, autophagosome (By similarity). Cytoplasm, P-body (By similarity). Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. May also local
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