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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Src substrate cortactin

UniprotKB/SwissProt ID: SRC8_MOUSE (Q60598)

Gene Name: Cttn

Synonyms: Ems1

Organism: Mus musculus (Mouse).

Function: Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection, dendritic spine (By similarity). Cell projection, dendrite (By similarity). Note=Associated with membrane ruffles and lamellipodia.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map05100Bacterial invasion of epithelial cells
map04530Tight junction
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000108
IPR001452
IPR003134
IPR015503

The S-nitrosylation sites of SRC8_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1112HEYQSKLSKH C SQVDSVRGFG HHHHHHHHHH H HHHHCCCCCC 3.32%MC0522178444-
2112HEYQSKLSKH C SQVDSVRGFG HHHHHHHHHH H HHHHCCCCCC 3.32%MC0520837516in vivo