UniprotKB/SwissProt ID: SRC8_MOUSE (Q60598)
Gene Name: Cttn
Synonyms: Ems1
Organism: Mus musculus (Mouse).
Function: Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection, dendritic spine (By similarity). Cell projection, dendrite (By similarity). Note=Associated with membrane ruffles and lamellipodia.
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