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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Serine/threonine-protein kinase 16

UniprotKB/SwissProt ID: STK16_HUMAN (O75716)

Gene Name: STK16

Synonyms: MPSK1, PKL12, TSF1

Organism: Homo sapiens (Human).

Function: Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, perinuclear region. Membrane; Lipid-anchor (By similarity). Note=Associates with Golgi and Golgi-derived vesicles (By similarity).

PDB :
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Protein disease:
Disease database Database Entry Disease information
OMIM604719SERINE/THREONINE PROTEIN KINASE 16; STK16 ;;PKL12, MOUSE, HOMOLOG OF;; TRANSFORMING GROWTH F
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000719
IPR008271
IPR011009

The S-nitrosylation sites of STK16_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
153GHFYALKRIL C HEQQDREEAQ CCEEEEEEEE C CCCCCHHHHH 2.86%HC0424105792-