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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Syntaxin-binding protein 1

UniprotKB/SwissProt ID: STXB1_MOUSE (O08599)

Gene Name: Stxbp1

Organism: Mus musculus (Mouse).

Function: May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Network with metabolic pathway:
Kegg map ID Pathway Link
map04721Synaptic vesicle cycle
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001619

The S-nitrosylation sites of STXB1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1110RAAHVFFTDS C PDALFNELVK CEEEEEECCC C CHHHHHHHHH 3.83%MC0124895380-
2180ERLAEQIATL C ATLKEYPAVR HHHHHHHHHH H HHHCCCCEEE 2.06%MC0722588120-