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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Syntaxin-binding protein 1

UniprotKB/SwissProt ID: STXB1_RAT (P61765)

Gene Name: Stxbp1

Synonyms: Unc18a

Organism: Rattus norvegicus (Rat).

Function: May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04721Synaptic vesicle cycle
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001619

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3C98 X-ray 2.60 A A1-594Link
3PUJ X-ray 3.31 A A/B1-594Link
4JEH X-ray 2.50 A A1-594Link
4JEU X-ray 3.20 A A3-592Link

The S-nitrosylation sites of STXB1_RAT

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1110RAAHVFFTDS C PDALFNELVK CEEEEEECCC C CHHHHHHHHH 3.83%RC0122178444-
2110RAAHVFFTDS C PDALFNELVK CEEEEEECCC C CHHHHHHHHH 3.83%RC0116418269in vitro