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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glycine--tRNA ligase

UniprotKB/SwissProt ID: SYG_HUMAN (P41250)

Gene Name: GARS

Organism: Homo sapiens (Human).

Function: Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Mitochondrion.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD02617Charcot-Marie-tooth disease, axonal, type 2D
HPRD02617Neuronopathy, distal hereditary motor, type V
Network with metabolic pathway:
Kegg map ID Pathway Link
map00970Aminoacyl-tRNA biosynthesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000738
IPR002314
IPR002315
IPR004154
IPR006195

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2PME X-ray 2.90 A A55-739Link
2PMF X-ray 2.85 A A55-739Link
2Q5H X-ray 3.00 A A55-739Link
2Q5I X-ray 2.80 A A55-739Link
2ZT5 X-ray 2.50 A A55-739Link
2ZT6 X-ray 3.08 A A55-739Link
2ZT7 X-ray 2.70 A A55-739Link
2ZT8 X-ray 3.35 A A55-739Link
2ZXF X-ray 3.40 A A55-739Link

The S-nitrosylation sites of SYG_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1466IEIVGCADRS C YDLSCHARAT EEEEEEEECC C CCHHHHHHCC 2.97%HC0319483679in vivo
2471CADRSCYDLS C HARATKVPLV EEECCCCCHH H HHHCCCCCCE 3.65%HC0119483679in vivo