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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Synaptotagmin-2

UniprotKB/SwissProt ID: SYT2_RAT (P29101)

Gene Name: Syt2

Organism: Rattus norvegicus (Rat).

Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.

PDB :
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Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000008
IPR001565
IPR008973
IPR015428

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2NM1 X-ray 2.15 A B44-60Link
4ISR X-ray 2.59 A D/E/F40-60Link

The S-nitrosylation sites of SYT2_RAT

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1293YVPTAGKLTV C ILEAKNLKKM EEECCCEEEE E EEECCCCCCC 2.18%RC0422178444-
2293YVPTAGKLTV C ILEAKNLKKM EEECCCEEEE E EEECCCCCCC 2.18%RC0416418269in vitro