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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Tyrosine--tRNA ligase, cytoplasmic

UniprotKB/SwissProt ID: SYYC_HUMAN (P54577)

Gene Name: YARS

Organism: Homo sapiens (Human).

Function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD09153Charcot-Marie-tooth disease, dominant intermediate c
Network with metabolic pathway:
Kegg map ID Pathway Link
map00970Aminoacyl-tRNA biosynthesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001412
IPR002305
IPR002307
IPR002547
IPR012340
IPR014729
IPR015624

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1N3L X-ray 1.18 A A1-364Link
1NTG X-ray 2.21 A A/B/C/D359-528Link
1Q11 X-ray 1.60 A A1-364Link

The S-nitrosylation sites of SYYC_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1250DVKKKLKKAF C EPGNVENNGV HHHHHHHHHC C CCCCCCCCHH 8.03%HC1119483679in vivo
2501LQADFKISEE C IAQWKQTNFM HHHHCCCCCC C EEEECCCCCE 2.47%HC1219483679in vivo