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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Microtubule-associated protein tau

UniprotKB/SwissProt ID: TAU_MOUSE (P10637)

Gene Name: Mapt

Synonyms: Mtapt, Tau

Organism: Mus musculus (Mouse).

Function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04010MAPK signaling pathway
map05010Alzheimer's disease
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001084
IPR002955
IPR015562

The S-nitrosylation sites of TAU_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1614PVDLSKVTSK C GSLGNIHHKP CCCCCCCCCC C CCCCCCCCCC 4.48%MC0322178444-
2614PVDLSKVTSK C GSLGNIHHKP CCCCCCCCCC C CCCCCCCCCC 4.48%MC0319101475-