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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Tubulin beta chain

UniprotKB/SwissProt ID: TBB5_HUMAN (P07437)

Gene Name: TUBB

Synonyms: TUBB5

Organism: Homo sapiens (Human).

Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map05130Pathogenic Escherichia coli infection
map04540Gap junction
map04145Phagosome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000158
IPR000217
IPR002453
IPR003008
IPR008280
IPR013838

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3QNZ X-ray 2.20 A C429-438Link
3QO0 X-ray 2.30 A C422-441Link

The S-nitrosylation sites of TBB5_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
112REIVHIQAGQ C GNQIGAKFWE CEEEEEECCH H HHHHHHHHHH 5.60%HC1019483679in vivo
2239VSATMSGVTT C LRFPGQLNAD HHHHHHHHHC C CCCCCEEECC 1.55%HC0525040305in vivo
3239VSATMSGVTT C LRFPGQLNAD HHHHHHHHHC C CCCCCEEECC 1.55%HC0519483679in vivo
4303VFDAKNMMAA C DPRHGRYLTV HHHHCCCEEE C CCCCCHHHHH 5.55%HC0625040305in vivo