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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: T-complex protein 1 subunit alpha

UniprotKB/SwissProt ID: TCPA_HUMAN (P17987)

Gene Name: TCP1

Synonyms: CCT1, CCTA

Organism: Homo sapiens (Human).

Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001844
IPR002194
IPR002423
IPR008950
IPR012715
The S-nitrosylation sites of TCPA_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
176EVEHPAAKVL C ELADLQDKEV CCCCHHHHHH H HHHHHCCCCC 4.51%HC0122178444-
276EVEHPAAKVL C ELADLQDKEV CCCCHHHHHH H HHHHHCCCCC 4.51%HC0119483679in vivo
376EVEHPAAKVL C ELADLQDKEV CCCCHHHHHH H HHHHHCCCCC 4.51%HC0120140087in vivo
4147IVNTDELGRD C LINAAKTSMS CCCCCCHHHH H HHHHHHHHHH 3.86%HC0322178444-
5147IVNTDELGRD C LINAAKTSMS CCCCCCHHHH H HHHHHHHHHH 3.86%HC0318335467-
6147IVNTDELGRD C LINAAKTSMS CCCCCCHHHH H HHHHHHHHHH 3.86%HC0319366988-
7147IVNTDELGRD C LINAAKTSMS CCCCCCHHHH H HHHHHHHHHH 3.86%HC0319483679in vivo
8236PKRIVNAKIA C LDFSLQKTKM EEEEECCEEE E EECCCCCCHH 4.22%HC0419483679in vivo
9357QAEEVVQERI C DDELILIKNT EEEEEEEEEE C CHHHHHHHHH 7.26%HC0322178444-
10357QAEEVVQERI C DDELILIKNT EEEEEEEEEE C CHHHHHHHHH 7.26%HC0318335467-
11357QAEEVVQERI C DDELILIKNT EEEEEEEEEE C CHHHHHHHHH 7.26%HC0319366988-
12357QAEEVVQERI C DDELILIKNT EEEEEEEEEE C CHHHHHHHHH 7.26%HC0319483679in vivo
13357QAEEVVQERI C DDELILIKNT EEEEEEEEEE C CHHHHHHHHH 7.26%HC0320140087in vivo
14397EMERSLHDAL C VVKRVLESKS HHHHHHHHHH H HHHHHHHCCC 3.38%HC012212679
(Cys242)		in vitro
15397EMERSLHDAL C VVKRVLESKS HHHHHHHHHH H HHHHHHHCCC 3.38%HC0119483679in vivo