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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: T-complex protein 1 subunit epsilon

UniprotKB/SwissProt ID: TCPE_HUMAN (P48643)

Gene Name: CCT5

Synonyms: CCTE, KIAA0098

Organism: Homo sapiens (Human).

Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Protein disease:
Disease database Database Entry Disease information
HPRD06468Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001844
IPR002194
IPR002423
IPR008950
IPR012718

The S-nitrosylation sites of TCPE_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1181TTLGSKVVNS C HRQMAEIAVN HHCCHHHHHH H HHHHHHHHHC 2.30%HC0519483679in vivo
2377TKDKMLVIEQ C KNSRAVTIFI CCEEEEEEEC C CCCCEEEEEE 2.67%HC012212679in vitro
3407EAKRSLHDAL C VIRNLIRDNR HHHHHHHHHH H HHHHHHHCCC 2.28%HC0119483679in vivo