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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Talin-1

UniprotKB/SwissProt ID: TLN1_MOUSE (P26039)

Gene Name: Tln1

Synonyms: Tln

Organism: Mus musculus (Mouse).

Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell surface. Cell junction, focal adhesion. Note=Colocalizes with LAYN at the membrane ruffles (By similarity). Loc

PDB :
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Network with metabolic pathway:
Kegg map ID Pathway Link
map04510Focal adhesion
map05166HTLV-I infection
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000299
IPR002558
IPR011993
IPR014352
IPR015009
IPR015224
IPR015710

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1SJ7 X-ray 2.50 A A/B/C482-655Link
1SJ8 X-ray 2.60 A A482-789Link
1T01 X-ray 2.06 A B605-628Link
1U89 NMR - A755-889Link
1XWX Model - A486-889Link
1Y19 X-ray 2.60 A B/D/F/H/J/L209-410Link
1ZW3 X-ray 3.30 A B1628-1652Link
2B0H NMR - A1843-1973Link
2G35 NMR - A305-404Link
2JSW NMR - A2300-2482Link
2KBB NMR - A1655-1822Link
2KC1 NMR - A1-85Link
2KC2 NMR - A86-202Link
2KGX NMR - A1655-1822Link
B311-401
2KMA NMR - A1-202Link
2KVP NMR - A1815-1973Link
2L10 NMR - A1206-1357Link
2L7A NMR - A787-911Link
2L7N NMR - A1046-1207Link
2LQG NMR - A913-1044Link
2QDQ X-ray 2.20 A A/B2494-2541Link
2X0C X-ray 2.00 A A1359-1659Link
3DYJ X-ray 1.85 A A/B1974-2293Link
3IVF X-ray 1.94 A A1-400Link
3S90 X-ray 1.97 A C/D1512-1546Link
4F7G X-ray 2.05 A A206-405Link
B1654-1847

The S-nitrosylation sites of TLN1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
129FEPSTMVYDA C RMIRERIPEA CCHHHHHHHH H HHHHHCCCCC 2.50%MC0222865876in vivo
2286ERKIFQAHKN C GQMSEIEAKV HHHHHHHHHH H HCCCHHHHHH 4.83%MC0321278135in vitro
31199AKAVTQALNR C VSCLPGQRDV HHHHHHHHHH H HHCCCCCCCH 2.28%MC0820925432in vivo
41661MRDKAPGQLE C ETAIAALNSC HHHHCCCHHH H HHHHHHHHHH 8.39%MC0120925432in vivo
52408RMVAAATNNL C EAANAAVQGH HHHHHHHHHH H HHHHHHHHCC 3.48%MC1320925432in vivo