UniprotKB/SwissProt ID: TLR13_MOUSE (Q6R5N8)
Gene Name: Tlr13
Organism: Mus musculus (Mouse).
Function: Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endosome membrane; Single-pass type I membrane protein.
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