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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Troponin C, slow skeletal and cardiac muscles

UniprotKB/SwissProt ID: TNNC1_MOUSE (P19123)

Gene Name: Tnnc1

Synonyms: Tncc

Organism: Mus musculus (Mouse).

Function: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Network with metabolic pathway:
Kegg map ID Pathway Link
map04260Cardiac muscle contraction
map05410Hypertrophic cardiomyopathy (HCM)
map05414Dilated cardiomyopathy
map04020Calcium signaling pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001125
IPR002048
IPR011992

The S-nitrosylation sites of TNNC1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
135DIFVLGAEDG C ISTKELGKVM HHHCCCCCCC C CCHHHHHHHH 3.25%MC0721278135in vitro
235DIFVLGAEDG C ISTKELGKVM HHHCCCCCCC C CCHHHHHHHH 3.25%MC0722865876in vivo