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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Toll-interacting protein

UniprotKB/SwissProt ID: TOLIP_MOUSE (Q9QZ06)

Gene Name: Tollip

Organism: Mus musculus (Mouse).

Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (Probable).

Network with metabolic pathway:
Kegg map ID Pathway Link
map04620Toll-like receptor signaling pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000008
IPR003892
IPR008973
IPR009060

The S-nitrosylation sites of TOLIP_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1229PPPAVAPQPR C NEEDLKAIQD CCCCCCCCCC C CHHHHHHHHH 10.79%MC0222178444-
2229PPPAVAPQPR C NEEDLKAIQD CCCCCCCCCC C CHHHHHHHHH 10.79%MC0219101475-