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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: DNA topoisomerase 2-alpha

UniprotKB/SwissProt ID: TOP2A_MOUSE (Q01320)

Gene Name: Top2a

Synonyms: Top-2, Top2

Organism: Mus musculus (Mouse).

Function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001154
IPR001241
IPR002205
IPR003594
IPR011558
IPR012542
IPR013506
IPR013757
IPR013758
IPR013759
IPR013760

The S-nitrosylation sites of TOP2A_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1391TLQAKSFGST C QLSEKFIKAA CCCCCEEEEH E ECHHHHHHHH 4.03%MC0420925432in vivo
2404SEKFIKAAIG C GIVESILNWV HHHHHHHHHH H HHHHHHHHHH 2.48%MC1320925432in vivo
3996KVFKLQSSLT C NSMVLFDHVG HHHCCEEEEC E EEEEEECCCC 4.27%MC0120925432in vivo