UniprotKB/SwissProt ID: TOP2B_MOUSE (Q64511)
Gene Name: Top2b
Organism: Mus musculus (Mouse).
Function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus.
| |
|
