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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Tissue-type plasminogen activator

UniprotKB/SwissProt ID: TPA_HUMAN (P00750)

Gene Name: PLAT

Organism: Homo sapiens (Human).

Function: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted, extracellular space.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04610Complement and coagulation cascades
map05202Transcriptional misregulation in cancer
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000001
IPR000083
IPR000742
IPR001254
IPR001314
IPR006209
IPR006210
IPR009003
IPR013032
IPR013806

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1A5H X-ray 2.90 A A/B311-562Link
1BDA X-ray 3.35 A A/B298-562Link
1PK2 NMR - A209-298Link
1PML X-ray 2.38 A A/B/C213-298Link
1RTF X-ray 2.30 A B311-562Link
1TPG NMR - A36-126Link
1TPK X-ray 2.40 A A/B/C211-298Link
1TPM NMR - A36-85Link
1TPN NMR - A36-85Link

The S-nitrosylation sites of TPA_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1118CQCPEGFAGK C CEIDTRATCY EECCCCCCCC C CCCCCCCCCC 2.17%HC0222178444-
2118CQCPEGFAGK C CEIDTRATCY EECCCCCCCC C CCCCCCCCCC 2.17%HC021325644in vitro
3244DGSDEKKKLY C IYVAIGQKRS CEEECCCCCC C CCCCCCCCCC 2.94%HC0424105792-