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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Triosephosphate isomerase

UniprotKB/SwissProt ID: TPIS_HUMAN (P60174)

Gene Name: TPI1

Synonyms: TPI

Organism: Homo sapiens (Human).

Function:

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD01833Triosephosphate isomerase deficiency
HPRD01833Triosephosphate isomerase manchester
Network with metabolic pathway:
Kegg map ID Pathway Link
map00010Glycolysis / Gluconeogenesis
map00051Fructose and mannose metabolism
map00562Inositol phosphate metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000652
IPR013785

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1HTI X-ray 2.80 A A/B39-286Link
1WYI X-ray 2.20 A A/B39-286Link
2IAM X-ray 2.80 A P60-74Link
2IAN X-ray 2.80 A C/H/M/R60-74Link
2JK2 X-ray 1.70 A A/B39-286Link
2VOM X-ray 1.85 A A/B/C/D39-286Link
4BR1 X-ray 1.90 A A/B41-286Link
4E41 X-ray 2.60 A C/H60-74Link

The S-nitrosylation sites of TPIS_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1218IYGGSVTGAT C KELASQPDVD EEECCCCHHH H HHHHCCCCCC 46.33%HC1219483679in vivo