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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Tropomyosin alpha-4 chain

UniprotKB/SwissProt ID: TPM4_HUMAN (P67936)

Gene Name: TPM4

Organism: Homo sapiens (Human).

Function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04260Cardiac muscle contraction
map05410Hypertrophic cardiomyopathy (HCM)
map05414Dilated cardiomyopathy
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000533

The S-nitrosylation sites of TPM4_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1154EERAEVSELK C GDLEEELKNV HHHHHHHHHH H HHHHHHHHHH 8.84%HC0220140087in vivo