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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Tripeptidyl-peptidase 2

UniprotKB/SwissProt ID: TPP2_MOUSE (Q64514)

Gene Name: Tpp2

Organism: Mus musculus (Mouse).

Function: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Translocates to the nucleus in responce to gamma-irradiation.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000209
IPR003006
IPR015500

The S-nitrosylation sites of TPP2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1150PIHRVALAEA C RKQEEFDIAN CCCCCCCCHH H HHHHHEECCC 4.15%MC0120925432in vivo
2209VWHDGETWRA C VDSNENGDLS ECCCCCEEEE E EECCCCCCCC 2.34%MC0921278135in vitro
3614LREGLHYTEV C GYDIASPNAG CCCCCEEEEE E EECCCCCCCC 3.21%MC0820925432in vivo