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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Tumor necrosis factor receptor superfamily member 10A

UniprotKB/SwissProt ID: TR10A_HUMAN (O00220)

Gene Name: TNFRSF10A

Synonyms: APO2, DR4, TRAILR1

Organism: Homo sapiens (Human).

Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.

Protein disease:
Disease database Database Entry Disease information
OMIM603611TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 10A; TNFRSF10A ;;DEATH RECEPTOR 4; DR4;;
Network with metabolic pathway:
Kegg map ID Pathway Link
map04210Apoptosis
map04650Natural killer cell mediated cytotoxicity
map05162Measles
map04060Cytokine-cytokine receptor interaction
map05164Influenza A
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000488
IPR001368
IPR011029

The S-nitrosylation sites of TR10A_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1336VTVQSPGEAQ C LLGPAEAEGS CCCCCCCCHH H HHCHHHHHHC 4.34%HC1222178444-
2336VTVQSPGEAQ C LLGPAEAEGS CCCCCCCCHH H HHCHHHHHHC 4.34%HC1216847314-