Protein Name: Tumor necrosis factor receptor superfamily member 10A
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UniprotKB/SwissProt ID: TR10A_HUMAN (O00220)
Gene Name: TNFRSF10A
Synonyms: APO2, DR4, TRAILR1
Organism: Homo sapiens (Human).
Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.
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Protein disease:
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Disease database |
Database Entry |
Disease information | OMIM | 603611 | TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 10A; TNFRSF10A ;;DEATH RECEPTOR 4; DR4;; |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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