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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: TNF receptor-associated factor 5

UniprotKB/SwissProt ID: TRAF5_HUMAN (O00463)

Gene Name: TRAF5

Synonyms: RNF84

Organism: Homo sapiens (Human).

Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (Probable). Cytoplasm, cytosol.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04064NF-kappa B signaling pathway
map05222Small cell lung cancer
map05168Herpes simplex infection
map05169Epstein-Barr virus infection
map05200Pathways in cancer
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001293
IPR001841
IPR002083
IPR008974
IPR012227
IPR013083
IPR013322

The S-nitrosylation sites of TRAF5_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1161KDLKEHLSAS C QFRKEKCLYC HHHHHHHHHC C CCCCCCCCCC 4.42%HC0124105792-