UniprotKB/SwissProt ID: TRI33_HUMAN (Q9UPN9)
Gene Name: TRIM33
Synonyms: KIAA1113, RFG7, TIF1G
Organism: Homo sapiens (Human).
Function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Note=In discrete nuclear dots resembling nuclear bodies (By similarity).
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