logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Tripartite motif-containing protein 72

UniprotKB/SwissProt ID: TRI72_MOUSE (Q1XH17)

Gene Name: Trim72

Synonyms: Mg53

Organism: Mus musculus (Mouse).

Function: Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane, sarcolemma. Cytoplasmic vesicle membrane. Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000315
IPR001841
IPR001870
IPR003877
IPR003879
IPR006574
IPR013083

The S-nitrosylation sites of TRI72_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1144PQQKMQLQEA C MRKEKTVAVL HHHHHHHHHH H HHHHHHHHHH 2.39%MC0121278135in vitro
2144PQQKMQLQEA C MRKEKTVAVL HHHHHHHHHH H HHHHHHHHHH 2.39%MC0122865876in vivo
3242KPQTEFLMKF C LVTSRLQKIL CCHHHHHHHH H HHHHHHHHHH 2.20%MC0421278135in vitro
4242KPQTEFLMKF C LVTSRLQKIL CCHHHHHHHH H HHHHHHHHHH 2.20%MC0422865876in vivo
5313VVSSSGRRVE C SDQKAPPAGE EEECCCEEEE E CCCCCCCCCC 5.06%MC0721278135in vitro
6456PGPVYPIFDV C WHDKGKNAQP CCCCCEEEEC C CCCCCCCCCC 2.62%MC0221278135in vitro
7456PGPVYPIFDV C WHDKGKNAQP CCCCCEEEEC C CCCCCCCCCC 2.62%MC0222865876in vivo