UniprotKB/SwissProt ID: U2AF1_HUMAN (Q01081)
Gene Name: U2AF1
Synonyms: U2AF35, U2AFBP
Organism: Homo sapiens (Human).
Function: Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus speckle.
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