UniprotKB/SwissProt ID: U2AF2_HUMAN (P26368)
Gene Name: U2AF2
Synonyms: U2AF65
Organism: Homo sapiens (Human).
Function: Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.
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